Fulvestrant Powder

Fulvestrant Information
Fulvestrant powder is a selective estrogen receptor down-regulator indicated for treating estrogen receptor-positive metastatic breast disease in postmenopausal women whose condition has worsened despite anti-estrogen therapy. Many bad breast cells have estrogen receptors (ERs), and estrogen stimulates the growth of these cells. It is a pure estrogen receptor antagonist without partial estrogen-like agonistic effects. By binding, blocking, and degrading estrogen receptors, it comprehensively blocks signal transduction pathways, and its affinity with ER is close to that of estrogen.
Fulvestrant can compete with estrogen by binding to estrogen receptors but does not play the role of estrogen. It can also change the receptor's shape to no longer combine with estrogen, reducing estrogen stimulation in sarcoma. Generally, anti-estrogen therapy is first used clinically, that is, to reduce the estrogen content in the body. If the curative effect of this therapy is not significant, or the disease progresses rapidly, fulvestrant can be added. Fulvestrant API is the only anti-estrogen drug that can be widely used clinically after the failure of tamoxifen. Since this drug is an endocrine therapy, it will not cause common adverse reactions of chemotherapy, so it has good patient compliance. Because of the remarkable effect of fulvestrant, more and more manufacturers appear in the market. If you are looking for a pure fulvestrant, don't hesitate to contact Xi'an Sonwu.

Certificate Of Analysis

Where To Buy Fulvestrant
Xi'an Sonwu Biotech Co. ltd. is a manufacturer and distributor with over ten years of experience. It has extensive and stable cooperation with countries worldwide in the Americas, Asia, Europe, and Oceania. Xi'an Sonwu has always insisted on product quality first; serving every customer well and satisfying every customer is Xi'an Sonwu's pursuit. In addition, Xi'an Sonwu strives to handle every detail to minimize costs and allow customers to get products with high-cost performance. Based on these, customers have given good feedback on the product. So if you need fulvestrant, don't hesitate to contact Xi'an Sonwu.
Xi'an Sonwu ultimately ensured the product's quality and also supplied the samples. Here is the quantity.

Customers' Good Comment

What Are Estrogen Receptor Antagonists
Anti-estrogen drugs An estrogen antagonist is a drug that antagonizes the action of estrogen on the estrogen receptor, a compound that regulates estrogen levels. According to different mechanisms of action, anti-estrogen drugs can be divided into estrogen receptor antagonists and selective estrogen receptor modulators. Among them, aromatase inhibitors can reduce estrogen production to achieve the effect of declining estrogen. In contrast, estrogen receptor antagonists and selective estrogen receptor modulators mainly reduce estrogen by inhibiting estrogen effect.
As we all know, estrogen and testosterone are the original chemical substances in the body that maintain the normal sexual function and characteristics of the human body. Usually, hormones make cells, such as sperm or breast cells, multiply, and egg cells mature for fertilization. But sometimes, the target cells multiply in disorder, causing cytopathic changes in the hormone-affected tissue. Women's breast, uterine, and ovarian diseases are all related to hormones, men's prostate diseases are closely related to hormones.
Fulvestrant is a traditional Chinese medicine preparation for this type of anti-cervical disease, and it is a life-long drug for treating cervical disorders. It is not a targeted drug but an estrogen receptor antagonist for the endocrine therapy of breast diseases. It is an anti-estrogen drug that can block the action of estrogen and achieve the effect and purpose of shrinking and inhibiting sarcoma. It is an endocrine therapy drug mainly used to treat postmenopausal estrogen receptor-positive, metastatic breast disease, recurrent breast disease, and other diseases. Fulvestrant has a similar affinity to estradiol and can competitively bind to estrogen receptors, help block the receptors, inhibit estrogen binding, and simultaneously change the shape of the receptors to shrink and kill bad cells effect.

What Is Fulvestrant Used For
1. For breast diseases
In an experiment of fulvestrant for advanced breast disease, there was no difference between fulvestrant and other endocrine therapy drugs regarding survival, TTP, clinical benefit, or objective response rate. Still, the incidence of joint disease with endocrine therapy drugs was higher than the latter fulvestrant. Fulvestrant powder also has a good effect on patients with HER-2 overexpression and hormone receptor-positive advanced breast disease. In addition, the clinical research of fulvestrant combined with farnesyl transferase inhibitors in treating patients with hormone receptor-positive breast diseases also has a good effect. Fulvestrant has no estrogen-like effect, can significantly inhibit the endometrial thickening caused by estrogen stimulation, and has no estrogen agonist activity on the endometrium of healthy postmenopausal women.

2. For endometrial diseases
A phase II clinical study of fulvestrant treats recurrent or metastatic endometrial disease. The results showed that only 18% of 22 patients with ER-negative disease had a stable condition, no complete remission, and PR patients. All patients' resistance was well tolerated, and no patients discontinued treatment due to toxicity. It showed that fulvestrant has good tolerance and effectiveness. Although the objective effective rate is low, the disease stability rate is high, and it has a specific curative effect on recurrent or metastatic endometrial diseases. In addition, fulvestrant combined with gefitinib in treating advanced postmenopausal women with non-small cell lung disease has good tolerance and curative effect. For postmenopausal women with non-small cell lung disease, combining targeted and endocrine therapy drugs is expected to improve the efficacy further.

Fulvestrant Mechanism Of Action
Fulvestrant API is a steroid anti-estrogen drug whose chemical structure is similar to estradiol. The difference is that it has a linking group at the 7α position; it is an alkylamine analog of 17β-estradiol, It can antagonize the effect of estrogen by occupying ER and inhibit the gene activation stimulated by this estrogen, so it affects the estrogen-related processes necessary for cell cycle; its affinity with ER is close to that of estrogen. Apoptosis is critical in maintaining homeostasis and may be another central mechanism of the fulvestrant's therapeutic effect.
First, fulvestrant binds to receptors and downregulates them so that estrogen no longer binds to those receptors. Second, fulvestrant degrades the estrogen receptors to which it binds. This mechanism inhibits the growth of human breast disease cell lines resistant to tamoxifen and sensitive to estrogen.
Fulvestrant blocks the trophic effects of estrogens without any partial agonistic (estrogen-like) effects. Its mechanism of action is related to the downregulation of estrogen receptor (ER) protein levels. In vitro studies have confirmed that fulvestrant is a reversible inhibitor of the growth of tamoxifen-resistant and estrogen-sensitive human breast disease (MCF-7) cell lines. Fulvestrant inhibits the growth of implanted MCF-7 xenografts and tamoxifen-resistant breast cell xenografts.

What Are The Side Effects Of Fulvestrant
Common adverse reactions after medication are as follows:
Hepatobiliary system: high liver enzymes (ALT, AST, ALP) and bilirubin are common, and liver failure, hepatitis, and V-GT are occasionally seen.
Gastrointestinal System: Nausea, vomiting, diarrhea.
Nervous system: headache.
Vascular: hot flashes.
Metabolism and Nutrition: Anorexia.
Skin and Subcutaneous Tissue: Rash.
Infection and infestation: Urinary tract infection.
Rabbit immune system: allergic reaction.

In addition, because the structure of this drug is similar to that of estradiol, it can interfere with the estradiol level in the immunoassay, resulting in a false increase in the estradiol level. Therefore, please inform the doctor that you are using fulvestrant when you see a doctor so as not to affect the diagnosis and treatment of the disease.

Factory
1. Xi'an Sonwu Biotech Co., Ltd has adequate Stock because its factory produces, manufactures, and stores the products. Xi'an Sonwu has a clean and tidy, well-ordered branch of production. With the leader of Xi'an Sonwu, researchers can continuously develop pure new products.
2. Xi'an Sonwu Biotech Co., Ltd has strict requirements on personnel, such as production men, testing men, and salespeople. Provide unyielding data support and after-sales service for each product.

Certificate

Package

Logistics

Besides guaranteeing product quality, the other most crucial thing is to help customers receive the package smoothly. So, Xi'an Sonwu can supply all kinds of couriers according to different needs.

FAQ
Fulvestrant API requires long-term and continuous medication to achieve the desired effect. For people with renal insufficiency, pregnant women, etc., it needs to be used with caution because the drug may cause damage to the kidney, aggravate the deterioration of kidney function, and affect the average growth and development of the fetus.

Patients with advanced breast disease need to evaluate the effect of fulvestrant when using fulvestrant. In case of worsening, combined treatment with targeted radiotherapy, surgery, and other programs is required to control the disease's development effectively. Allergic, need to avoid use.
If you want to know fulvestrant price, you can contact Xi'an Sonwu. Click the email then you get high-quality fulvestrant powder.
Email: sales@sonwu.com

Suositut Tagit: fulvestrant powder, China, suppliers, manufacturers, factory, wholesale, buy, price, bulk, pure, raw, supply, for sale